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The numeric criteria for bioaccumulation, outlined in the Persistence and Bioaccumulation Regulations of CEPA 1999, are based on bioaccumulation data for freshwater aquatic species (fish) only and for substances that preferentially partition to lipids. As a result, the criteria may not completely reflect the bioaccumulation potential of PFOA that is preferentially partitioning in the proteins of liver steroids, blood and kidney in terrestrial and marine mammals. There is experimental evidence indicating that PFOA is not highly bioaccumulative in fish.

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